Publications
1) Andhare, P. & Laidlaw, B. J.* B cells regulate somatic hypermutation rate to preserve high-affinity clones. Immunol. Cell Biol. 103, 415–417 (2025). *Corresponding Author
2) Pérez-Pérez, L. & Laidlaw, B. J.* Polarization of the memory B-cell response. J. Leukoc. Biol. 117, qiae228 (2024). *Corresponding Author
3) Anupam, K. & Laidlaw, B. J.* In Vivo CRISPR/Cas9-Mediated Gene Ablation in Murine B Cells. Methods Mol. Biol. 2826, 79–91 (2024). *Corresponding Author
4) Hanson, C.H., Henry, B., Andhare, P., Lin, F.J., Pak. H, Turner, J.S., Adams, L.J., Liu, T., Fremont, D.H., Ellebedy, A.H., Laidlaw, B.J.* CD62L expression marks a functionally distinct subset of memory B cells. Cell Rep. 42, 113542 (2023). *Corresponding Author
5) Henry, B. and Laidlaw, B. J.* Functional heterogeneity in the memory B-cell response. Curr Opin Immunol 80, 102281 (2023). *Corresponding Author
6) Lin, F. J., …, Laidlaw, B. J.*. SARS-CoV-2 booster vaccination rescues attenuated IgG1 memory B cell response in primary antibody deficiency patients. Front Immunol 13, 1033770 (2022).
7) Chen, C. and Laidlaw, B. J.* Development and function of tissue-resident memory B cells. Advances in Immunology 155, 1–38 (2022). *Corresponding Author
8) Song, W. et al. Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers. Immunity 55, 290-307.e5 (2022).
9) Laidlaw, B. J.* and Ellebedy, A. H. The germinal centre B cell response to SARS-CoV-2. Nat Rev Immunol 22, 7–18 (2022). *Corresponding Author
10) Duan, L., Liu, D., Chen, H., Mintz, M.A., Chous, M.Y., Kotov, D.I., Xu, Y., An, J., Laidlaw, B.J., and Cyster, J. (2021) Follicular dendritic cells restrict interleukin-4 availability in germinal centers and fosters memory B cell generation. Immunity 21, 1082-1093. PMCID: PMC7442689
11) Castellanos, C.A., Ren, X., Gonzalez, S.L., Li, H.K., Schroeder, A.W., Liang H., Laidlaw, B.J., …, and Shin, J.S. (2021) Lymph Node Resident Dendritic Cells Drive TH2 Cell Development Involving MARCH1. Science Immunology. 6, eabh0707. PMID: 36452961
12) Laidlaw, B.J., Duan. L., Xu, Y., Vazquez, S.E., and Cyster, J. (2020) The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nat. Immunol. 21, 1082-1093. PMCID: PMC7442689
13) Laidlaw, B.J.*, and Cyster, J. (2020). Transcriptional regulation of memory B cell differentiation. Nat. Rev. Immunol. 21. 209-220. PMCID: PMC7538181 *Corresponding Author
14) Gagnon, J.D., Kageyama, R., Shehata, H.M., Fassett, M.S., Mar, D., Wigton, E.J., Johannson, K., Litterman, A.J., Odorizzi, P., Simeonov, D., Laidlaw, B.J., …, Marson, A. Matloubian, M., Sanjabi, S., and Ansel, M. (2019) mir-15/16 restrain memory T cell differentiation, cell cycle, and survival. Cell Reports. 28 (8), 2169-2184. PMCID: PMC6715152
15) Laidlaw, B.J., Gray, E.E., Zhang, Y., Ramírez-Valle, F., and Cyster, J. (2019) Sphingosine-1 phosphate receptor 2 restrains egress of gd T cells from the skin. J. Exp. Med. 216 (7), 1487-1496.
16) Guan, T., Dominguez, C.X., Amezquita, R.A., Laidlaw, B.J., Cheng, J., Henao-Mejia, J., Williams, A., Flavell, R.A., Lu, J., and Kaech, S.M. (2018) ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates. J. Exp. Med. 215 (4), 1153–1168. PMCID: PMC5881466
17) Weinstein, J.S., Laidlaw, B.J., Lu, Y., Wang, J., Shulz, V., Li, N., Herman, E.I., Kaech, S.M., Gallagher, P., and Craft, J. (2018) STAT4 and T-bet control follicular helper T cell development in viral infections. J. Exp. Med. 215 (1), 337-355. PMCID: PMC5748849
18) Laidlaw, B.J., Lu. Y., Amezquita, R.A., Weinstein, J.S., Vander Heiden J.A., Gupta, N.T., Kaech, S.M., and Craft, J. (2017). Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Sci. Immunol. 2 (16), eaan4767. PMCID: PMC5846620
19) Laidlaw, B.J., and Cyster, J.G. (2017) Interfer’n with antibody responses. Sci. Immunol. 1 (4), eaan1836. PMCID: N/A
20) Laidlaw, B.J., Schmidt, T.H., Green, J.A., Allen, C.D.C., Okada, T., and Cyster, J. (2017) The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells. J. Exp. Med. 214 (3), 639–649. PMCID: PMC5339677
21) Laidlaw, B.J.*, Craft, J., and Kaech, S.M. (2016). The multifaceted role of CD4+ T cells in CD8+ T cell memory. Nat. Rev. Immunol. 16 (2), 102-111. PMCID: PMC4860014 *Corresponding Author
22) Ray, J.P., Staron, M.M., Shyer, J.A., Ho, P.-C., Marshall, H.D., Gray, S.M., Laidlaw, B.J., Araki, K., Ahmed, R., Kaech, S.M., et al. (2015). The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity 43, 690–702. PMCID: PMC4618086
23) Laidlaw, B.J., Cui, W., Amezquita, R.A., Gray, S.M., Guan, T., Lu, Y., Kobayashi, Y., Flavell, R.A. Kleinstein, S.H., Craft, J., and Kaech, S.M. (2015). Production of IL-10 by CD4+ regulatory T cells during resolution of infection promotes the maturation of memory CD8+ T cells. Nat. Immunol. 16, 871-879. PMCID: PMC4713030
24) Marshall, H.D., Ray, J.P., Laidlaw, B.J., Zhang, N., Gawande, D., Staron, M.M., Craft, J., and Kaech, S.M. (2014). The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. eLife 4. e04851. PMCID: PMC4337607
25) Backer, R.A., Helbig, C., Gentek, R., Kent, A., Laidlaw, B.J., Dominguez, C.X., de Souza, Y.S., van Trierum, S.E., van Beek, R., Rimmelzwaan, G.F., et al. (2014). A central role for Notch in effector CD8(+) T cell differentiation. Nat. Immunol. 15, 1143–1151. PMCID: PMC4232996
26) Laidlaw, B.J., Zhang, N., Marshall, H.D., Staron, M.M., Guan, T., Hu, Y., Cauley, L.S., Craft, J., and Kaech, S.M. (2014). CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity 41, 633–645. PMCID: PMC4324721
27) Parish, I.A., Marshall, H.D., Staron, M.M., Lang, P.A., Brüstle, A., Chen, J.H., Cui, W., Tsui, Y.-C., Perry, C., Laidlaw, B.J., et al. (2014). Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J. Clin. Invest. 124, 3455–3468. PMCID: PMC4109559
28) Ray, J.P., Marshall, H.D., Laidlaw, B.J., Staron, M.M., Kaech, S.M., and Craft, J. (2014). Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity 40, 367–377. PMCID: PMC3992517
29) Kumamoto, Y., Linehan, M., Weinstein, J.S., Laidlaw, B.J., Craft, J.E., and Iwasaki, A. (2013). CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity 39, 733–743. PMCID: PMC3819035
30) Laidlaw, B.J., Decman, V., Ali, M.-A.A., Abt, M.C., Wolf, A.I., …, Angelosanto, J.M., Artis, D., Erikson, J., et al. (2013). Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity. PLoS Pathog. 9, e1003207. PMCID: PMC3597515
31) Decman, V., Laidlaw, B.J., Doering, T.A., Leng, J., Ertl, H.C.J., Goldstein, D.R., and Wherry, E.J. (2012). Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors. J. Immunol. 188, 1933–1941. PMCID: PMC3320034
32) Monticelli, L.A., Sonnenberg, G.F., Abt, M.C., Alenghat, T., Ziegler, C.G.K., Doering, T.A., Angelosanto, J.M., Laidlaw, B.J., Yang, C.Y., Sathaliyawala, T., et al. (2011). Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol. 12, 1045–1054. PMCID: PMC3320042
33) Decman, V., Laidlaw, B.J., Dimenna, L.J., Abdulla, S., Mozdzanowska, K., Erikson, J., Ertl, H.C.J., and Wherry, E.J. (2010). Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection. J. Immunol. 184, 5151–5159. PMCID: N/A